Associate Engineer, Drug Substance at Revolution Medicines

Ideal for a recent chemical engineering graduate with 0-3 years of experience in small-molecule drug substance process R&D. A Bachelor's degree in chemical engi

Work type: hybrid

Location: Redwood City, California, United States

Salary: $119,000 – $149,000/yr

Type: Full-time

Summary

Ideal for a recent chemical engineering graduate with 0-3 years of experience in small-molecule drug substance process R&D. A Bachelor's degree in chemical engineering or a related field is required. **What makes it worth a look...** Revolution Medicines is offering a hybrid role in Redwood City, California, with a base salary between $119,000 and $149,000 annually. **You might be a good fit if you...** * Are familiar with synthetic organic chemistry and can review/create Process Flow Diagrams (PFDs) and Process & Instrumentation Diagrams (P&IDs). * Have experience writing, reviewing, and updating Master and Executed Batch Records (MBRs and EBRs). * Possess knowledge of ICH guidelines, cGMP guidelines, and are proficient with Microsoft Office Suite, including Visio. * Understand principles of quality by design (QbD) and risk assessment tools like FMEA and HAZOP.

Job Description

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

• Work closely with DS, Analytical Development-QC and Quality teams to enable large-scale commercial manufacturing readiness, through process development and optimization studies conducted according to the principles of quality by design (QbD), establish control strategy and process characterization studies using tools such as design of experiment (DOE) studies.

• Support demonstration that large-scale manufacturing of DS can be conducted safely by proactively identifying risks and developing mitigation strategies (e.g. using reaction calorimetry and principles of FMEA and HAZOP).

• Support the transition of manufacturing of drug substance from clinical-stage through Process Performance Qualification (PPQ) to commercial-stage, and support commercial-stage activities (e.g. Continuous Performance Verification, CDMO relationship, etc.).

• Support technology transfer, process familiarization, and manufacturing at CDMOs, including PIP as needed.

• Review protocols, manufacturing batch records, development and campaign reports for clinical-scale and commercial-scale manufacturing.

• Utilize internal AI platform(s) to improve workflows and efficiency, for both internal team and cross-functional benefit.

• Communicate effectively within cross functional project teams.

• Travel to CDMO for the oversight of development activities and manufacturing (up to approximately 25%).

• BS chemical engineering or related discipline with 0-3 years industrial experience, in small-molecule chemical / drug substance process research and development .

• Familiar with synthetic organic chemistry.

• Familiar with review, update and creation of Process Flow Diagrams (PFDs) and Process & Instrumentation Diagrams (P&IDs).

• Familiar with writing, reviewing and updating Master and Executed Batch Records (MBRs and EBRs).

• Fluent in use of Microsoft Office products (Excel, Power Point, Word, Visio).

• Knowledge of current ICH guidelines, cGMP guidelines, and relevant industry practices.

• Strong problem solving skills with sound technically driven decision-making ability.

• Effective written and verbal communication skills and interpersonal skillsAn innovative team-player with high energy for our dynamic company environment.

• Experience using AI platform(s) to improve workflows and efficiency, especially for Engineering calculations.

• Previous experience in chemical/small molecule manufacturing campaigns.

• Previous experience with Process Safety evaluations.

The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

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