Director, Precision Medicine and Companion Diagnostics at Revolution Medicines

You're a highly experienced biomarker or diagnostics professional with a PhD and 6+ years of relevant industry experience, or an MS with 10+ years, specializing

Work type: hybrid

Location: Redwood City, California, United States

Salary: $211,000 – $264,000/yr

Type: Full-time

Summary

You're a highly experienced biomarker or diagnostics professional with a PhD and 6+ years of relevant industry experience, or an MS with 10+ years, specializing in companion diagnostic development or clinical oncology biomarkers. **What makes it worth a look...** Revolution Medicines is offering a full-time, hybrid role in Redwood City, California, with a base salary range of USD 211,000 - 264,000 per year, focused on advancing novel targeted therapies for RAS-addicted cancers. **You might be a good fit if you...** * Have at least 3 years of specific experience in CDx development. * Are proficient in developing, outsourcing, and validating in vitro diagnostic assays. * Possess expertise in diagnostic regulations and interactions with global health authorities. * Are familiar with approaches like NGS-based tissue and ctDNA assays, PCR, and immunohistochemistry.

Job Description

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

To aid in this mission, the Translational Medicine (TM) team at RevMed is seeking a highly motivated, scientifically creative, and collaborative Director to work in a fast-paced environment within a cross-functional team. This role will be the Translational Medicine lead for precision medicine and companion diagnostic (CDx) development for RAS(ON) inhibitors across different solid cancer types. Activities will be centered around analytical and clinical validation of CDx tests to support global regulatory submissions.

Responsibilities:

• Drive the development and implementation of CDx strategies to support early and late-stage development of portfolio assets through registration and launch for individual clinical studies and/or molecule program.

• Lead or participate in joint project teams (JPTs) with diagnostic partners and internal cross-functional team members to ensure successful execution of analytical and clinical validation studies.

• Effectively collaborate with biomarker scientists, biomarker operations, clinical development, and clinical operations, to ensure successful collection and CDx testing of clinical trial samples.

• Collaborate closely with diagnostic partners and internal functions, including biostatistics, data management, medical writing, regulatory, and project management to enable analytical and clinical validation required for regulatory submissions and CDx approvals in global market.

• In working with functional head and finance, manage contracts, budgets, and timelines of key milestones associated with CDx development.

• Collaborate with clinical development and medical affairs to develop plans for publication of diagnostic test results in identifying biomarker-positive patient populations.

• Collaborate with commercial colleagues to develop patient identification strategies (e.g. access to diagnostic tests) for launch readiness.

• Highly experienced biomarker or diagnostics professional, PhD with 6+ years or MS with 10+ years of relevant industry experience with expertise in companion diagnostic development and/or clinical oncology biomarker.

• 3+ years of experience in CDx development is required.

• Direct the development, outsourcing and validation of clinically applicable in vitro diagnostic assays through the development lifecycle of molecules, including design, implement and oversee diagnostic testing and registration strategy and timely communication with key internal and external stakeholders.

• Provide expertise to development project team to ensure access to stat-of the-art approaches on fit for purpose diagnostic technologies employed in clinical development (e.g. NGS-based tissue and ctDNA assays, PCR, immunohistochemistry) are required.

• Experienced and serve as subject matter expert in diagnostic regulation and support the interactions with global health authorities regarding companion diagnostics development and submissions.

• Excellent scientific and business communication skills, strong interpersonal/collaboration and planning skills including influencing without authority.

• Ability to think critically and creatively and be able to work independently to determine appropriate resources for resolution of problems in a fast-pace innovate environment.

• A great teammate, who listens effectively and invites response and discussion.

• Commitment to Revolution Medicines’ Core Values: Tireless Commitment to Patients, Transformative Science, Exceptional Together, Total Integrity, Inclusiveness and Fairness.

• Experience in oncology drug development in the biopharmaceutical industry is preferred.

• Cross-functional experience in commercial and or medical aspects of companion diagnostics is a plus.

The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

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