Executive Director, Translational and Clinical Informatics at Revolution Medicines

You're a seasoned executive with a PhD or Master's in a relevant technical field and at least 13-16 years of experience leading informatics in biotech or pharma

Work type: hybrid

Location: Redwood City, California, United States

Salary: $265,000 – $331,000/yr

Type: Full-time

Summary

You're a seasoned executive with a PhD or Master's in a relevant technical field and at least 13-16 years of experience leading informatics in biotech or pharma R&D, with a deep understanding of the drug development lifecycle. **What makes it worth a look...** Revolution Medicines is offering a full-time, hybrid role in Redwood City, California, with a base salary between $265,000 and $331,000 annually. **You might be a good fit if you...** * Have experience deploying and managing on-prem/cloud hybrid solutions in AWS or Azure. * Understand relational databases and data lakehouse platforms like Databricks. * Have developed AI or AI-enabling applications for drug development. * Are proficient in statistical programming languages such as SAS and R.

Job Description

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

We are seeking an Executive Director, Translational and Clinical Informatics to lead and grow the informatics function supporting Translational Research, preclinical development and clinical data science. You will oversee strategy, execution, and delivery of informatics solutions that enable scientific insight, accelerate timelines, and ensure high-quality data and analytical results from research into clinical execution.

Key responsibilities include:

• Own the informatics strategy and portfolio for Translational Science, Nonclinical Development & Clinical Pharmacology and Quantitative Sciences.

• Lead, develop and mentor a high-performing team of informatics professionals and manage external vendors and partners.

• Translate scientific and business needs into innovative and practical informatics strategies that align end-user scientists, partner informatics teams and enable rapid execution.

• Oversee the full lifecycle of informatics platforms including requirements, vendor selection, implementation, validation (where needed) and support.

• Drive adoption of modern cloud, data and AI-enabled technologies to accelerate scientific insight and decision-making.

• Serve as the primary informatics partner to senior scientific and development stakeholders.

• Ensure systems meet applicable GxP, data integrity and compliance requirements.

• Apply a holistic, enterprise view encompassing people, process, data, technology, science, compliance and finance to deliver informatics solutions that solve real business problems efficiently.

• BS/MS/Ph.D. in Computer Science, Software Engineering, Research Informatics, Bioinformatics, Cheminformatics, or a related field.

• Significant experience in scientific informatics or data engineering within biotech or pharmaceutical R&D, with a minimum of 18+ years of relevant experience with a Bachelor’s degree, 16+ years of relevant experience with a Master’s degree or 13+ years of relevant experience with a Doctoral degree.

• Demonstrated success building, leading and scaling informatics organizations and managing strategic vendor partnerships.

• Deep understanding of drug development across translational science, biomarkers, nonclinical development, clinical pharmacology, preclinical safety and clinical data management.

• Experience deploying and managing on-prem/cloud hybrid informatics solutions in AWS or Azure.

• Strong understanding of relational databases and data lakehouse platforms such as Databricks.

• Demonstrated success owning the end-to-end lifecycle of scientific informatics platforms, from requirements gathering to build/buy to implementation and long-term support.

• Experience developing AI or AI-enabling applications supporting drug development.

• Strong understanding of data model design, scientific data integration and data visualization best practices.

• Experience with statistical programming languages such as SAS and R.

• Strong understanding of translational data types such as pathology, preclinical animal models patient biomarker data.

• Working knowledge of 21 CFR Part 11, EU Annex 11, GAMP 5, and risk-based validation approaches.

• Familiarity with clinical data platforms such as CTMS, EDC, eTMF, and IRT/RTSM systems.

The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

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