Senior Research Associate, Drug Product at Revolution Medicines

You're a seasoned scientist with a Master's degree and at least three years of relevant laboratory experience, or a Bachelor's degree with a minimum of five yea

Work type: hybrid

Location: Redwood City, California, United States

Salary: $106,000 – $126,000/yr

Type: Full-time

Summary

You're a seasoned scientist with a Master's degree and at least three years of relevant laboratory experience, or a Bachelor's degree with a minimum of five years in pre-formulation, formulation development, solid form screening, and analytical development. **What makes it worth a look...** This full-time, hybrid role at Revolution Medicines in Redwood City, California offers a salary of USD 106,000 - 126,000 per year. You'll be contributing to novel targeted therapies for patients with RAS-addicted cancers. **You might be a good fit if you...** * Are proficient in HPLC, NMR, PXRD, PLM, DSC, TGA, DVS, and PSD measurements. * Have experience in preclinical formulation screening and development. * Possess a strong understanding of basic organic and analytical chemistry. * Can maintain detailed laboratory notebook records using ELN.

Job Description

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

We have an opening for a full-time position as a Senior Research Associate position within the Drug Product function of our Pharmaceutical Development and Manufacturing (PDM) department. The position will be laboratory-based and responsible for preformulation studies, preclinical formulations development, and troubleshooting to support Revolution Medicines’ drug product development.

Responsibilities:

• Conduct solution and solid-state preformulation studies for RevMed research and development candidates (i.e. solubility, dissolution, excipient compatibility, stability studies, permeability and biopharmaceutics assessment, mechanical and processing properties).

• Conduct solid form related activities of new chemical entities during preclinical assessment and throughout the clinical development phases (ie. solid form screening, co-crystal and salt screening, solid form identification, and solid-state characterization).

• Support preclinical and (if needed) clinical formulation development.

• Collaborate with Research team and prepare preclinical formulations in a timely manner.

• Analyze formulations using suitable analytical methods to assess formulation stability, and dose analysis.

• Maintain good laboratory notebook record (i.e. ELN) to document formulation preparation process, test results, and lab activities.

• Help to maintain and manage lab activities, such as chemical inventories, calibrations, safety practices, new equipment acquisition, installation, and training.

• Conduct lab activities for troubleshooting formulation and solid form related issues.

• Write, revise, and update formulation protocols in a timely manner; support efforts to maintain and organize formulation protocols.

• Provide support to research and PDM organizations for requests related to API and formulations.

• Work closely with immediate supervisor on problems that may be of moderate complexity.

• BS with minimum 5 years or MS with minimum 3 years of the relevant laboratory experience in pre-formulation, formulation development, solid form screening, and analytical development.

• Proficient in laboratory analytical techniques, specifically in HPLC, NMR, PXRD, PLM, DSC, TGA, DVS, and PSD measurements.

• Experience in preclinical formulation screening and development to support in-house formulation preparations and management.

• Good understanding of basic organic chemistry and analytical chemistry.

• Excellent communication skills and a collaborative team player.

• Highly organized with strong attention to detail and documentation skills.

• Ability to multi-task and thrive in a fast-paced innovative environment.

• BS and/or MS degree in pharmaceutical sciences, chemistry, and chemical engineering, or related discipline.

• HPLC method development experience is preferred.

The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

View this job on nocollar jobs